· IntroductionThe emergence of psychosis in atrisk individuals results from interactions between genetic vulnerability and environmental factors, possibly involving dysregulation of the hypothalamicpituitaryadrenal axis. Hypercorticism was indeed described in schizophrenia and ultrahighrisk states, but its association with clinical outcome has yet to be demonstrated.
· TwoHit Hypothesis. The twohit hypothesis of schizophrenia suggests that a combination of genetic susceptibility coupled with a distinct developmental insult can prime an individual for a later event that ultimately leads to onset of the full clinical syndrome (Bayer et al., 1999).In the case of schizophrenia, multiple genetic liabilities have been suggested to interact with environmental ...
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Caution is warranted, however, as we observed no relationship between cerebellar changes and quantitative quetiapine parameters. Apart from the cerebellum, structural GM alterations related to illness progress have also been reported by the respective meta .
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· Background Elevated prolactin levels (hyperprolactinemia) are a frequent adverse effect of antipsychotic mediions, especially in young populations. Prolonged hyperprolactinemia may affect ual functioning and the onset and progression of puberty. Objective This study assessed potentially prolactinrelated treatmentemergent adverse events (PPRLTEAEs) and ual maturation during .
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Oldys, William, . 431 600dpi bitonal TIFF page images and SGML/XML encoded text University of Michigan Library Ann Arbor, Michigan 2011 June T147996 CW CW ECGR These pages may be freely searched and displayed. Permission must be received for subsequent distribution in print or electronically.
Special patient populations with schizophrenia have received little attention. These populations include adolescents, the elderly, substance abusers, and patients who are considered treatment ...
2021. Dopheide, Jörn F; Veit, Jonas; Ramadani, Hana; Adam, Luise; Papac, Lucija; Vonbank, Alexander; Kaspar, Mathias; Rastan, Aljoscha; Baumgartner, Iris; Drexel ...
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Although our understanding of psychotic disorders has advanced substantially in the past few decades, very little has changed in the standard of care for these illnesses since the development of atypical antipsychotics in the 1990s. Here, we integrate new insights into the pathophysiology with the increasing interest in early detection and prevention. First, we explore the role of Nmethyld ...
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The concept of ecosystem services (ESS) has been increasingly recognized for its potential in decision making processes concerning environmental policy. Multidisciplinary projects on rubber (Hevea brasiliensis) cultivation, integrating research on a variety of ESS, have been few and far between. More than three years of iterative workshops with regional stakeholders resulted in the development ...
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